ea0008oc2 | Growth and Development | SFE2004
Aldibbiat A
, Scougall KT
, Campbell SC
, Macfarlane WM
, Shaw JAM
Transdifferentiation of non-endocrine pancreatic cells towards a beta-cell phenotype may enable insulin independence in many individuals from a single donor. This will be dependent on near-physiological proinsulin biosynthesis, processing, storage and secretion. The aim of this study was to fully characterise endocrine potential of pancreatic acinar cells before and after transdifferentiation.Expression of exocrine/endocrine markers in the AR42J rat acin...